Effects of Pitavastatin, a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor, on Cardio-Ankle Vascular Index in Type 2 Diabetic Patients

• DOI: 10.5551/jat.281
• Publication Date: 2011-06-16T13:45:38Z
• Authors: Yoh Miyashita; Kei Endo; Atsuhito Saiki; Noriko Ban; Takashi Yamaguchi; Hidetoshi Kawana; Daiji Nagayama; Masahiro Ohira; Tomokazu Oyama; Kohji Shirai
• Keywords: Pitavastatin; Malondialdehyde

Aim: A novel device has been developed for measuring the cardio-ankle vascular index (CAVI) as an indicator of arterial stiffness. In this study, we evaluated effect pitavastatin on CAVI in type 2 diabetic patients.Methods: Forty-five diabetes mellitus patients with low-density lipoprotein cholesterolemia were enrolled and treated mg/day 12 months. Before after administration, HbA1c, serum lipids, malondialdehyde-LDL (MDA-LDL), urinary 8-hydroxy- 2'-deoxyguanosine (8-OHdG) measured.Results: After treatment months, significant decreases 8-OHdG, MDA-LDL observed. ΔCAVI significantly correlated ΔMDA-LDL.Conclusions: patients, may have oxidative stress-reducing effect, especially a state enhanced stress, be useful routine test diagnosis therapeutic monitoring atherosclerosis.