Relationships between Plasma Fatty Acid Composition and Coronary Artery Disease

• DOI: 10.5551/jat.5876
• Publication Date: 2011-06-15T11:22:51Z
• Authors: Hiroshige Itakura; Mitsuhiro Yokoyama; Masunori Matsuzaki; Yasushi Saito; Hideki Origasa; Yuichi Ishikawa; Shinichi Oikawa; Jun Sasaki; Hitoshi Hishida; Toru Kita; Akira Kitabatake; Noriaki Nakaya; Toshiie Sakata; Kazuyuki Shimada; Kunio Shirato; Yuji Matsuzawa
• Keywords: Unstable angina

Aim: The Japan EPA Lipid Intervention Study (JELIS) was the first prospective randomized clinical trial to demonstrate prevention of coronary events by pure eicosapentaenoic acid (EPA). aim this study examine relationships between various plasma fatty concentrations and risk in JELIS participants.Methods: In 15,534 participants, we calculated hazard ratio for major (sudden cardiac death, fatal or nonfatal myocardial infarction, unstable angina pectoris, angioplasty/stenting artery bypass grafting) relative on-treatment average level acids with Cox proportional model.Results: As a result intervention, concentration increased, but docosahexaenoic (DHA) did not. other measured decreased slightly. higher (hazard ratio=0.83, p=0.049, all participants ratio=0.71, p=0.018, intervention group), not DHA, inversely associated events. associations were significant. significantly (20%) group high (150 µg/mL more) compared that low (less than 87 µg/mL) group.Conclusion: disease is influenced variations composition. Among n-3 polyunsaturated acids, DHA exhibited differences correlation