Improved Efficiency of the Clinical Diagnostic Criteria for Familial Hypercholesterolemia in Children: A Comparison of the Japan Atherosclerosis Society Guidelines of 2017 and 2022

• DOI: 10.5551/jat.64513
• Publication Date: 2024-02-01T22:13:51Z
• Authors: Hai Ying Fu; Keiji Matsunaga; Tomoko Inoue; Ryosuke Tani; Kenzo Funatsuki; Takashi Iwase; Sonoko Kondo; Katsufumi Nishioka; Shigeru Ito; Tsuyoshi Sasaki; Ichiro Yokota; Yoichi Hoshikawa; Katsunori Yokoyama; Takuji Fujisawa; Masa-aki Kawashiri; Hayato Tada; Masayuki Takamura; Takashi Kusaka; Tetsuo Minamino
• Keywords: Genetic disorder

Familial hypercholesterolemia (FH) is a genetic disorder characterized by elevated low-density lipoprotein cholesterol (LDL-C) levels, which increases the risk of premature coronary artery disease. Early detection and treatment are vital, especially in children. To improve FH diagnosis children, Japan Atherosclerosis Society (JAS) released new guidelines July 2022. This study assessed compared sensitivity specificity clinical diagnostic criteria from JAS pediatric 2017