Association of Body Mass Index with Coronary Plaque Regression: 6-Month Prospective Study

• DOI: 10.5551/jat.e653
• Publication Date: 2011-06-16T13:45:38Z
• Authors: Shigemasa Tani; Ken Nagao; Takeo Anazawa; Hirofumi Kawamata; Shingo Furuya; Hiroshi Takahashi; Kiyoshi Iida; Michiaki Matsumoto; Takahiko Washio; Narimichi Kumabe; Atsushi Hirayama
• Keywords: Coronary atherosclerosis; Intravascular Ultrasound

Aim: Obesity is a well known strong risk factor for coronary artery disease (CAD). We prospectively investigated the influence of body mass index (BMI) on inhibitory effects pravastatin against development atherosclerosis.Methods: In 56 patients with stable CAD, 3-dimensional intravascular ultrasound was performed in matched segments at baseline and after 6-month treatment pravastatin.Results: The plaque volume significantly reduced by 11% (p<0.001 vs. baseline). percent positively correlated BMI (r=0.37, p<0.001), negatively serum total cholesterol / high-density lipoprotein ratio (r=0.27, p<0.05) leukocyte count p<0.05). Multivariate regression analysis showed that an independent predictor change (beta coefficient: 0.326; 95% CI: 0.003 to 0.037; No correlations were found between changes levels any other lipids, apolipoproteins, or hs-CRP.Conclusion: present study demonstrated increase attenuated pravastatin-induced atherosclerosis regression. results may provide new insight into framework obese CAD.