Phosphate and Coronary Artery Disease in Patients with Chronic Kidney Disease

• DOI: 10.5551/jat.rv22012
• Publication Date: 2023-09-27T22:57:28Z
• Authors: Hiroaki Ogata; Hirohito Sugawara; Masahiro Yamamoto; Hidetoshi Ito
• Keywords: Review; 3. Good health

Cardiovascular disease (CVD) is the leading cause of death in patients with chronic kidney (CKD). Both traditional and CKD-related factors are associated CVD CKD patients. Traditional that play an important role atherosclerotic process directly contribute to a higher risk coronary artery early-stage CKD. Among factors, CKD-mineral bone disorder plays critical pathomechanism nonatherosclerotic diseases, which increases cardiovascular morbidity mortality advanced Higher serum phosphate levels were significantly events all-cause or without An increased load, indirectly, promotes arterial medial calcification left ventricular hypertrophy, both predispose disease. Calciprotein particles form hyperphosphatemic state promote transformation vascular smooth muscle cells (VSMCs) into osteoblastic cells, thereby providing scaffold for artery. Increases fibroblast growth factor-23 disturbed vitamin D metabolism induced by excessive load significant development cardiomyocyte hypertrophy cardiac fibrosis. Recently, hyperphosphatemia was reported de novo cholesterol synthesis VSMCs macrophages, likely statin resistance end-stage This review outlines association between