Exosomes derived from olfactory mucosa mesenchymal stem cells attenuate cognitive impairment in a mouse model of Alzheimer's disease

• DOI: 10.5582/bst.2025.01065
• Publication Date: 2025-03-17T22:12:12Z
• Authors: Xiqi Hu; Ya-nan Ma; Jun Peng; Zijie Wang; Yuchang Liang; Ying Xia
• Keywords: Olfactory mucosa

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, neuroinflammation, and endoplasmic reticulum (ER) stress. In recent years, exosomes have garnered significant attention as potential therapeutic tool for diseases. This study, the first time, investigates neuroprotective effects of derived from olfactory mucosa mesenchymal stem cells (OM-MSCs-Exos) in AD further explore role low-density lipoprotein receptor-related protein 1 (LRP1) this process. Using an Aβ1-42-induced mouse model, we observed that OM-MSCs-Exos significantly improved function behavioral tests, reduced neuroinflammatory responses, alleviated ER stress, decreased neuronal apoptosis. Further analysis revealed exert modulating activation microglia astrocytes influencing stress response, process may involve LRP1. Although these findings support OM-MSCs-Exos, studies are required to their long-term stability, dose dependency, immunogenicity assess feasibility clinical applications.