Anti-tuberculosis treatment outcomes in HIV-infected adults exposed to isoniazid preventive therapy in Botswana

• DOI: 10.5588/ijtld.12.0314
• Publication Date: 2013-01-14T19:25:35Z
• Authors: T. Sibanda; Z. Tedla; S. Nyirenda; T. Agizew; M. Marape; A. G. Miranda; H. Reuter; J. L. Johnson; T. Samandari
• Keywords: Adult; Male; 0301 basic medicine; Botswana; Anti-HIV Agents; Incidence; Antitubercular Agents; HIV Infections; 3. Good health; 03 medical and health sciences; Treatment Outcome; Isoniazid; Humans; Tuberculosis; Drug Therapy, Combination; Female; Retrospective Studies

Eight public health clinics in Gaborone and Francistown, Botswana.To describe the characteristics outcomes of incident tuberculosis (TB) cases human immunodeficiency virus (HIV) infected adults exposed to isoniazid preventive therapy (IPT) with access antiretroviral anti-tuberculosis treatment.In 1995 HIV-infected adults, TB disease was excluded before commencing IPT. During after receipt 6 or 36 months IPT, symptomatic participants were evaluated using chest radiographs, sputum microscopy, cultures drug susceptibility testing (DST). Incident received ≥6 treatment.Seventy-five identified among 619 participants. The median duration IPT these (range 1-35), time initiation treatment 12 cessation. Antiretroviral (ART) initiated 37 cases. Culture positive 43/58 (74%) cultures. DST available for 38 cases, which six (16%) resistant (INH); 67/75 (89%) including four INH-monoresistant TB, completed cured.With prompt ART, excellent achieved a setting who developed disease.