Successful ‘9-month Bangladesh regimen’ for multidrug-resistant tuberculosis among over 500 consecutive patients

• DOI: 10.5588/ijtld.14.0100
• Publication Date: 2014-09-11T00:18:02Z
• Authors: K. J. M. Aung; A. Van Deun; E. Declercq; M. R. Sarker; P. K. Das; M. A. Hossain; H. L. Rieder
• Keywords: Gatifloxacin; Regimen; Pyrazinamide; Clofazimine; Directly Observed Therapy; Culture conversion; Sputum culture

Tuberculosis (TB) program, Damien Foundation Projects, Bangladesh.To summarize the outcome and its determinants of first treatment for multidrug-resistant TB using a standardized regimen consisting minimum 9 months.This was prospective, observational study gatifloxacin (GFX) based directly observed regimen, mainly with initial hospitalization. The 4-month intensive phase extended until sputum smear conversion. Patients were monitored culture up to 2 years after completion.Of 515 patients who met inclusion criteria successively enrolled from 2005 2011, 84.4% had bacteriologically favorable outcome. Due extensive disease delayed conversion, only half completed within months; however, 95% able complete 12 months. Eleven failed or relapsed, 93.1% 435 successfully treated at least months post-treatment follow-up. strongest risk factor unfavorable high-level fluoroquinolone (FQ) resistance, particularly when compounded by pyrazinamide (PZA) resistance. Low-level FQ resistance no effect on Amplification drug occurred once, in patient strain that initially susceptible kanamycin clofazimine.The excellent Bangladesh largely maintained. Bacteriological failures relapses rare, except among GFX notably presence PZA