2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy

• DOI: 10.5603/kp.2014.0212
• Publication Date: 2014-12-19T11:38:51Z
• Authors: Perry M. Elliott; Aris Anastasakis; Michael A. Borger; Martin Borggrefe; Franco Cecchi; Phillippe Charron; Albert Alain Hagege; Antoine Lafont; Giuseppe Limongelli; Heiko Mahrholdt; Wiliam J. McKenna; Jens Mogensen; Petros Nihoyannop...; Stefano Nistri; Petronella G. Pieper; Burkert Pieske; Claudio Rapezzi; Frans H. Rutten; Christoph Tillmanns; Hugh Watkins
• Keywords: Cardiac Amyloidosis

2D : two-dimensional 99mTc-DPD : 99mTechnetium-3,3-diphosphono- 1,2-propanodi-carboxylic acid ACE : angiotensin-converting enzyme AF : atrial fibrillation AL : amyloid light chain AR : aortic regurgitation ARB : angiotensin receptor blocker ATTR : amyloidosis-transthyretin type AV : atrioventricular BiVAD : biventricular assist device BNP : brain natriuretic peptide BPM : Beats per minute CCS : Canadian Cardiovascular Society CFC : cardiofacialcutaneous CHA2DS2-VASc : Congestive Heart failure, hypertension, Age ≥75 (doubled), Diabetes, Stroke Vascular disease, 65–74, and Sex (female) CMR : cardiac magnetic resonance CRT : resynchronization therapy CRT-D : therapy-defibrillator CRT-P : Cardiac therapy with a pacemaker CT : computed tomography DC : direct current DNA : deoxyribonucleic acid E/A : ratio of mitral peak velocity early filling (E) to late (A) E/e’ : transmitral flow annulus (e’) EACTS : European Association for Cardio-Thoracic Surgery ECG : electrocardiogram EF : ejection fraction EPS : electrophysiological study ESC : Society Cardiology FDA : (US) Food Drug Administration FHL1 : four half LIM domains 1 HAS-BLED : abnormal renal/liver function, stroke, bleeding history or predisposition, labile INR, elderly (>65 years), drugs/alcohol concomitantly HCM : hypertrophic cardiomyopathy hs-cTnT : high sensitivity troponin T HTS : throughput sequencing ICD : implantable cardioverter defibrillator ILR : loop recorder INR : international normalized ratio IUD : intrauterine device LA : left atrium LAMP-2 : lysosome-associated membrane protein 2 LBBB : bundle branch block LEOPARD : Lentigines, ECG abnormalities, Ocular hypertelorism, Pulmonary stenosis, Abnormal genitalia, Retardation growth, sensory-neural Deafness LGE : gadolinium enhancement LV : ventricular LVAD : ventricular device LVH : hypertrophy LVOTO : outlow tract obstruction MADIT-RIT : Multicenter Automatic Defibrillator Implantation Trial—Reduce Inappropriate Therapy MAPK : mitogen activated kinase MELAS : mitochondrial encephalomyopathy, lactic acidosis, stroke-like episodes MERFF : myoclonic epilepsy ragged red fibres MRA : mineralocorticoid antagonist MYBPC3 : myosin-binding C, cardiac-type MYH7 : myosin-7 (s-myosin heavy chain) MYL3 : myosin chain 3 NOAC : new oral anticoagulants NSVT : non-sustained tachycardia NT-proBNP : N-terminal pro peptide NYHA : New York Association OAC : anticoagulants o.d. : omni die (every day) PC-CMR : phase contrast resonance PDE5 : phosphodiesterase type 5 PET : positron emission tomography PRKAG2 : gamma-2 sub-unit the adenosine monophosphate-activated kinase RAAS : renin aldosterone system RV : right ventricular SAM : systolic anterior motion SCD : sudden death SAA : septal alcohol ablation S-ICD™ : Subcutaneous lead defibrillator SPECT : single photon tomography SSFP : steady-state free precession SVT : supraventricular tachycardia TOE : transoesophageal echocardiography TNNI3 : I, muscle TNNT2 : T, muscle TPM1 : tropomyosin alpha-1 chain TTE : transthoracic echocardiography TTR : transthyretin VF : fibrillation VKA : vitamin K antagonist VT : tachycardia WHO : World Health Organization

Guidelines summarize evaluate all available evidence at time writing process, on particular issue aim assisting health professionals in selecting best management strategies an individual patient, given condition, taking into account impact outcome, as well risk-benefit-ratio diagnostic therapeutic means. Guidelines recommendations should help make decisions their daily practice. However, final concerning patient must be made by responsible professional(s) consultation caregiver appropriate.

A great number have been issued recent years Cardiology (ESC) other societies organisations. Because clinical practice, quality criteria development guidelines established order transparent user. The formulating issuing ESC can found website (http://www.escardio.org/guidelines-surveys/esc-guidelines/about/Pages/rules-writing.aspx). represent official position topic are regularly updated.

Members this Task Force were selected involved medical care patients pathology. Selected experts field undertook comprehensive review published (including diagnosis, treatment, prevention rehabilitation) condition according Committee Practice (CPG) policy. A critical evaluation procedures was performed including assessment risk-benefit-ratio. Estimates expected outcomes larger populations included, where data exist. level strength recommendation options weighed graded predefined scales, outlined Tables 1 2 .

The …