Aspirin resistance in patients with impaired renal functions

• DOI: 10.5603/kp.a2013.0286
• Publication Date: 2013-10-21T07:51:19Z
• Authors: Hale Unal Aksu; Ender Oner; Mehmet Erturk; Huseyin Aksu; Nilgun Isıksacan; Begum Ozalp; Gulsah Akture; Ertan Akbay; Leyla Ozer; Mustafa Kemal Erol
• Keywords: Mean platelet volume

Background: Cardiovascular diseases (CVD) are the leading cause of death in patients with chronic kidney (CKD). Aspirin resistance (AR) worsens prognosis CVD. Aim: The aim this study was to detect AR prevalence patient group. Methods: 203 (mean age 61.84 ± 11.51 years, 128 [63.1%] male) stable coronary artery disease included were grouped into four groups according their estimated glomerular filtration rate (eGFR) values. Multiplatetest used determine AR. Platelet aggregation results presented as unit (AU) × min and valuesover 300 AU accepted Results: 61 (30.04%) whole population found have Differences detected between ratios multiplate values (p = 0.006 p 0.002). ratio highest group 4 (eGFR < 30 mL/min/1.73 m 2 ) and/or on haemodialysis therapy, whereas there little difference amongthe other three groups. In multivariate analysis, while status independently related female sex (OR 2.31,CI 1.14–4.65, 0.019) mean platelet volume (MPV) 1.68, CI 1.21–2.33, 0.002), test MPV (b 0.265, 0.0001) eGFR –0.165, 0.025). Conclusions: be high severe CKD patients, especially but not mild moderate patients. This increased may affect who already an risk for cardiovascular complications.