The Expression of PNPLA3 Polymorphism could be the Key for Severe Liver Disease in NAFLD in Hispanic Population

• DOI: 10.5604/01.3001.0010.5282
• Publication Date: 2017-10-17T07:07:39Z
• Authors: Leonardo A. Martínez; Elena Larrieta; Juan J. Calva; David Kershenobich; Aldo Torre
• Keywords: Adult; Male; Hepatic steatosis; Heterozygote; Adolescent; Specialties of internal medicine; Polymorphism, Single Nucleotide; Severity of Illness Index; 03 medical and health sciences; Gene Frequency; Non-alcoholic Fatty Liver Disease; Risk Factors; NAFLD; Humans; Genetic Predisposition to Disease; Mexico; Aged; 0303 health sciences; Homozygote; Membrane Proteins; Lipase; Middle Aged; 3. Good health; Phenotype; Patatine-like phosphatas in domain 3; RC581-951; Case-Control Studies; Sllele I148M; Female

Nonalcoholic fatty liver disease (NAFLD) encompasses: (SS), steatohepatitis (NASH) with or without fibrosis and cirrhosis. Patatine-like phosphatas in domain 3 (PNPLA3; adiponutrin; SNP rs738409 C/G, M148I) shows anabolic catabolic activities on lipid metabolism significant association to content; however, I148M demographics ethnics, as its role NAFLD have not been fully elucidated.