Potential protective effect of ovocystatin on aging-related cognitive impairment in rats

• DOI: 10.5604/01.3001.0010.7670
• Publication Date: 2017-12-29T19:26:54Z
• Authors: Bartłomiej Stańcz...; Maria Rutkowska; Marta Lemieszewska; Marta Jakubik-Wit...; Jakub Gburek; Krzysztof Gołąb; Katarzyna Juszczy...; Tadeusz Trziszka; Joanna Rymaszewska
• Keywords: Cognitive Decline

Introduction: Increased occurrence of cognitive deficits in mild impairment is related with the phenomenon aging within population. Cystatin C has been associated cysteine protease inhibiting properties as well an induction autophagy and proliferation that can potentially be used adjuvant treatment decline. The aim study was to evaluate effect ovocystatin, which structurally biologically similar cystatin C, on functions experimental young rat models. Material/Methods: (four-month-old) (ten-month-old) Wistar Crl: Wi (Han) rats received ovocystatin (i.p.) for 12 days at a dose 200 20 μg/rat, respectively. Cognitive were determined using Morris water maze. Results: Ovocystatin μg/rat improved performance old maze test via increasing spent time distance traveled target zone but differences not statistically significant (p>0.05). results highlight important role cystatins play neurodegenerative processes influence they have functions. Furthermore, obtained findings suggest may or decline dementia, further morphological, biochemical immunohistochemical studies are needed.