Hepatitis E Virus Genotype 1 Cases Imported to Portugal from India, 2016
Adult
Male
0301 basic medicine
Genotype
Acute hepatitis E
HCC INF
Specialties of internal medicine
Emigrants and Immigrants
India
Severity of Illness Index
03 medical and health sciences
Hepatitis E virus
Humans
Travel
Portugal
Hepatitis E - India
Hepatitis - Transmission
Emigration and Immigration
Middle Aged
Hepatitis E
3. Good health
Treatment Outcome
RC581-951
DNA, Viral
HCC PAT CLIN
DOI:
10.5604/01.3001.0010.8667
Publication Date:
2018-02-14T12:52:52Z
AUTHORS (10)
ABSTRACT
Hepatitis E in industrialized countries is mainly associated with genotype 3 hepatitis E virus (HEV) and normally causes a sporadic self-limiting disease in immunocompetent individuals. Unlike genotype 3, genotypes 1 and 2 circulate in developing countries, produce severe disease and occur in the epidemic form. Hepatitis E occurring in travellers returning from endemic areas in developing countries is not a novel epidemiological occurrence, however the vast majority of cases remain to be genetically studied. The present study describes two cases of severe acute hepatitis E that required hospitalization for 6 and 9 days in two individuals of Indian nationality that had recently migrated to Portugal to work. The retrieved HEV sequences both belonged to genotype 1 and had a high degree of nucleotide sequence identity, clustering with strains isolated in India and Nepal, in 2013 and 2014. Confirmed HEV genotypes of increased pathogenicity like genotype 1 are being introduced into otherwise naïve populations of industrialized countries such as European countries with consequences difficult to predict. As far as we know the present study is the first in Portugal to describe and genetically characterize imported cases of hepatitis E infection caused by HEV genotype 1.
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