Astrocyte-targeted Overproduction of IL-10 Reduces Neurodegeneration after TBI

• DOI: 10.5607/en21035
• Publication Date: 2022-07-04T03:04:23Z
• Authors: Mahsa Shanaki-Bav...; Beatriz Almolda; Berta González; Bernardo Castellano
• Keywords: Proinflammatory cytokine; Infiltration (HVAC)

Traumatic brain injury is the greatest cause of disability and death in young adults developed world. The outcome for a TBI patient determined by severity injury, not only from initial insult but, especially, as product secondary injury. It proposed that this directly linked to neuro-inflammation, with production pro-inflammatory mediators, activation resident glial cells infiltration peripheral immune cells. In context, anti-inflammatory treatments are one most promising therapies dampen inflammatory response associated reduce sense, main objective present study elucidate effect local IL-10 neurological after TBI. For purpose, cryogenic lesion was caused transgenic animals overproducing under GFAP promoter on astrocytes (GFAP-IL10Tg mice) neuro-protection, microglial leukocyte recruitment were evaluated. Our results showed protective neurons at early time-points TBI, correlation shift profile towards down-regulating phenotype lower cytokines. Concomitantly, we observed reduction BBB leakage together modifications into affected area. conclusion, modifies neuro-inflammatory shifting it neuro-protective conditions. These point candidate improve neuro-inflammation