Celiac Disease Increases the Risk of Multiple Sclerosis: Evidence from Mendelian Randomization and the Role of CCL19

• DOI: 10.5607/en25009
• Publication Date: 2025-04-15T02:05:01Z
• Authors: Seongjin Lim; Junhua Wu; Yeon Woo Kim; Sun Woo Lim; Juhee Shin; Hyo Jung Shin; Sang Ryong Kim; Dong Woon Kim
• Keywords: Mendelian Randomization; Mendelian inheritance

Celiac disease (CeD) is an autoimmune disorder triggered by gluten, primarily affecting the small intestine but potentially impacting other systems, including nervous system through gut-brain axis. This study employed Mendelian randomization (MR) to explore causal relationships between CeD and several neurological disorders, with a particular focus on multiple sclerosis (MS). Utilizing genetic data from OpenGWAS Finngen databases, we applied various MR methods, Inverse Variance Weighted (IVW), IVW-multiplicative random effects (MRE), weighted median (WM), MR-Egger, robust adjusted profile score (RAPS), investigate these associations. The analysis revealed no significant relationship positive association MS was found (IVW OR=1.1919, 95% CI: 1.0851~1.3092, p=0.0002). Further indicated that mediator CCL19 plays role in pathway MS, suggesting may be key factor immune response linking conditions. mediation effect highlights potential mechanism which increases risk of developing MS. These findings emphasize complexity indicating need for further research understand connections better their clinical implications.