Andrographis paniculata protects against brain hippocampus and cerebellum from mercury chloride induced damage by attenuating oxidative stress

• DOI: 10.5620/eaht.2022027
• Publication Date: 2022-10-05T02:24:44Z
• Authors: Eduitem Sunday Otong; Wusa Makena; Abel Yashim Solomon; Sebastine Anthony...; Aisha Aminu; Rachael Henry
• Keywords: Andrographis Paniculata

Mercury chloride (HgCl2) is a neurotoxicant that remains health hazard despite numerous efforts to reduce its levels in the environment. The use of medicinal plants treating various diseases and other toxic agents has grown popular owing their effectiveness affordable rates. Andrographis paniculata (A. paniculata) plant with astringent detoxifying characteristics widely used worldwide for antioxidant benefits. This study aimed investigate possible protective effects A. aqueous extract against HgCl2-induced memory impairment, oxidative stress, brain damage. Twenty-five adult Wistar rats were randomly divided into five groups: control, HgCl2 0.5 mg/kg, HgCl2+AP 250 500 or HgCl2+Ascorbic acid 200 mg/kg. For 28 days, administrations given through oral gavage once day. injection resulted increased glutamate concentrations brain, production stress. Memory impairment was prevented paniculata-treated groups by balancing AChE dopamine activities, which then lowered concentration, avoided improved histopathological alterations brain. alleviated increasing index, regulating neurotransmitter levels, reducing