Complex dental anomalies in a belatedly diagnosed cleidocranial dysplasia patient

• DOI: 10.5624/isd.2015.45.3.187
• Publication Date: 2015-09-15T07:02:34Z
• Authors: Hui Lu; Binghui Zeng; Dongsheng Yu; Xiangyi Jing; Bin Hu; Wei Zhao; Yiming Wang
• Keywords: Cleidocranial Dysplasia; Dental anomalies; Congenital disorder; Odontoma

Cleidocranial dysplasia (CCD) is a rare autosomal domi nant skeletal disorder.The typical changes found in CCD patients are short stature, frontal and parietal bos sing, open cranial sutures or the delayed closure thereof, presence of Wormian bones, absent hypoplastic cla vicles, maxilla, iliac wings, brachydactyly.The associated dental anomalies supernumerary teeth, retention primary eruption impaction perma nent dentition.The development teeth rarely affected.Patients generally referred for treat ment due to along with appearance midface dysplasia, slop ing shoulders. 1The worldwide prevalence this syndrome approximately 1/1,000,000 individuals.Mutations runt-related transcription factor 2 (RUNX2) gene res ponsible two thirds patients. 2RUNX2 codes runtrelated protein, which important skeletogenesis development. 3,4This report describes com plex that were observed using conebeam computed tomography (CBCT) imaging 20yearold patient.These novel manifestations, CBCT imaging, treatment discussed. Case ReportWritten informed consent was obtained from all par ticipants study,