Association between the Incidence of Chemotherapy with Cisplatin and Fluorouracil-induced Vomiting and the Body's Water Balance

• DOI: 10.5649/jjphcs.41.846
• Publication Date: 2016-12-09T17:11:41Z
• Authors: Hirotake Hida; Tomomi Tsubai; Mio Takeuchi; Aya Goto; Mitsuho Otsuka; Yumiko Komori; Hiroshi Kato; Noriko Miyazaki; Masayuki Miyazaki; Kiyofumi Yamada; Yukihiro Noda
• Keywords: 03 medical and health sciences; 0302 clinical medicine

In a cisplatin (a highly emetogenic anti-cancer agent)-containing regimen, administrations of fluid replacement and/ or diuretic drugs are performed to relieve nephrotoxicity.Such treatments will alter the body＇s water balance, which may be partially responsible for chemotherapy-induced vomiting progression.We thus examined whether balance correlates with incidence and/or risk factors chemotherapyinduced nausea and (CINV) in women CINV factor) inpatients receiving treatment cisplatincontaining regimen.The severity was significantly associated increased body patients multiple (double), but not single factors.Therefore, our findings suggest that is decreased by keeping constantly restriction hydration (eg short hydration) consolidation antiemetics, when female (double) receive cisplatin-containing regimen.Key words -cisplatin,