Comorbidity and Mortality of Narcolepsy: A Controlled Retro- and Prospective National Study

• DOI: 10.5665/sleep.2706
• Publication Date: 2013-05-31T19:05:52Z
• Authors: Poul Jennum; Rikke Ibsen; Stine Knudsen; Jakob Kjellberg
• Keywords: Adult; Aged, 80 and over; Male; Denmark; Comorbidity; Middle Aged; 3. Good health; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Humans; Female; Prospective Studies; Registries; Aged; Narcolepsy; Retrospective Studies

To identify the factual morbidity and mortality of narcolepsy in a controlled design. National Patient Registry. All national diagnosed patients (757) with health information at least 3 years prior to after diagnose narcolepsy. Randomly selected four citizens (3,013) matched for age, sex, socioeconomic status from Danish Civil Registration System Statistics. Increased diagnosis included (odds ratio, 95% confidence interval):- diseases endocrine, nutritional, metabolic systems (2.10, 1.32-3.33); nervous system (5.27, 3.65-7.60); musculoskeletal (1.59, 1.23-2.05); other abnormal symptoms laboratory findings (1.66, 1.25-2.22). After diagnosis, experienced (2.31, 1.51-3.54), (9.19, 6.80-12.41), (1.70, 1.28-2.26), eye (1.67, 1.03-2.71), respiratory (1.84, 1.21-2.81). Specific diagnoses were diabetes (2.4, 1,2-4.7, P < 0.01), obesity (13.4, 3.1-57.6, 0.001), sleep apnea (19.2, 7.7-48.3, disorders (78.5, 11.8-523.3, chronic obstructive pulmonary disease (2.8, 1.4-5.8, lower back pain (2.5, 1.4-4.2, arthrosis/arthritis 1.3-4.8, observation neurological (3.5, 1.9-6.5, (1.7, 1.2-2.5, rehabilitation (5.0, 1.5-16.5, 0.005). There was trend towards greater (P = 0.07). Patients present higher several even thereafter. The rate due slightly but not significantly higher.