Comorbidity and Mortality of Narcolepsy: A Controlled Retro- and Prospective National Study

Adult Aged, 80 and over Male Denmark Comorbidity Middle Aged 3. Good health Young Adult 03 medical and health sciences 0302 clinical medicine Humans Female Prospective Studies Registries Aged Narcolepsy Retrospective Studies
DOI: 10.5665/sleep.2706 Publication Date: 2013-05-31T19:05:52Z
ABSTRACT
To identify the factual morbidity and mortality of narcolepsy in a controlled design. National Patient Registry. All national diagnosed patients (757) with health information at least 3 years prior to after diagnose narcolepsy. Randomly selected four citizens (3,013) matched for age, sex, socioeconomic status from Danish Civil Registration System Statistics. Increased diagnosis included (odds ratio, 95% confidence interval):- diseases endocrine, nutritional, metabolic systems (2.10, 1.32-3.33); nervous system (5.27, 3.65-7.60); musculoskeletal (1.59, 1.23-2.05); other abnormal symptoms laboratory findings (1.66, 1.25-2.22). After diagnosis, experienced (2.31, 1.51-3.54), (9.19, 6.80-12.41), (1.70, 1.28-2.26), eye (1.67, 1.03-2.71), respiratory (1.84, 1.21-2.81). Specific diagnoses were diabetes (2.4, 1,2-4.7, P < 0.01), obesity (13.4, 3.1-57.6, 0.001), sleep apnea (19.2, 7.7-48.3, disorders (78.5, 11.8-523.3, chronic obstructive pulmonary disease (2.8, 1.4-5.8, lower back pain (2.5, 1.4-4.2, arthrosis/arthritis 1.3-4.8, observation neurological (3.5, 1.9-6.5, (1.7, 1.2-2.5, rehabilitation (5.0, 1.5-16.5, 0.005). There was trend towards greater (P = 0.07). Patients present higher several even thereafter. The rate due slightly but not significantly higher.
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