Abnormalities of Lipoprotein Concentrations in Obstructive Sleep Apnea Are Related to Insulin Resistance

• DOI: 10.5665/sleep.4678
• Publication Date: 2015-04-30T19:01:29Z
• Authors: Alice Liu; James Cardell; Danit Ariel; Cindy Lamendola; Fahim Abbasi; Sun H. Kim; Tyson H. Holmes; Vanessa Tomasso; Hafasa Mojaddidi; Kaylene Grove; Clete A. Kushida; Gerald M. Reaven
• Keywords: Dyslipidemia; Lipoprotein(a)

Prevalence of cardiovascular disease (CVD) is increased in patients with obstructive sleep apnea (OSA), possibly related to dyslipidemia these individuals. Insulin resistance also common OSA, but its contribution OSA unclear. The study's aim was define the relationships among abnormalities lipoprotein metabolism, clinical measures and insulin resistance. Cross-sectional study. severity defined by apnea-hypopnea index (AHI) during polysomnography. Hypoxia were expressed as minimum mean oxygen saturation, desaturation index. quantified determining steady-state plasma glucose (SSPG) concentrations suppression test. Fasting lipid/lipoprotein evaluation performed vertical auto profile methodology. Academic medical center. 107 nondiabetic, overweight/obese adults. Lipoprotein particles did not correlate AHI or any hypoxia measures, nor there differences noted categories severity. By contrast, even after adjustment for age, sex, BMI, SSPG positively correlated triglycerides (r = 0.30, P < 0.01), very low density (VLDL) subclasses (VLDL1+2) 0.21–0.23, 0.05), subclass 4 (LDL4) 0.01). negatively high (HDL) −0.38, 0.001) (HDL2 HDL3) −0.32, −0.43, apolipoprotein A1 −0.33, Linear trends across tertiles significant. Pro-atherogenic (OSA) are resistance, degree hypoxia. may represent link between OSA-related risk.