A Randomized Controlled Trial of Continuous Positive Airway Pressure on Glucose Tolerance in Obese Patients with Obstructive Sleep Apnea

• DOI: 10.5665/sleep.5312
• Publication Date: 2015-12-31T16:00:47Z
• Authors: Neus Salord; Ana Maria Fortuna; Carmen Monasterio; Mercè Gasa; Antonio Pérez; Maria R. Bonsignore; Núria Vilarrasa; Josep Maria Monts...; Mercedes Mayos
• Keywords: Sleep; Positive airway pressure

Obstructive sleep apnea (OSA) is associated with an increased prevalence of metabolic syndrome (MetS), even in patients morbid obesity. Our goal was to address whether continuous positive airway pressure (CPAP) treatment improved glucose metabolism this population.A prospective randomized controlled trial performed severe OSA obesity without diabetes two university referral hospitals. Patients received conservative (CT) versus CPAP for 12 weeks. MetS components, homeostasis model assessment insulin resistance (HOMA-IR) and oral tolerance were assessed at baseline after treatment.A total 80 completed the study (42 38 CT patients). After w treatment, weight loss similar both groups physical activity, MetS, HOMA-IR did not change either group. In group impaired (IGT) reversed nine IGT developed none, whereas five (P = 0.039 Fisher test). Changes 2-h plasma load greater than (CPAP: -0.5 ± 1.5 CT: 0.33 1.9, P 0.007).The improvement morbidly obese obstructive apnea, changes resistance, supports peripheral treatment.NCT 01029561.