Loss of Sleep Affects the Ultrastructure of Pyramidal Neurons in the Adolescent Mouse Frontal Cortex

• DOI: 10.5665/sleep.5644
• Publication Date: 2016-03-31T21:00:14Z
• Authors: Luisa de Vivo; Aaron B. Nelson; Michele Bellesi; Juliana Noguti; Giulio Tononi; Chiara Cirelli
• Keywords: Sleep restriction; Sleep; Frontal lobe

Study ObjectiveThe adolescent brain may be uniquely affected by acute sleep deprivation (ASD) and chronic restriction (CSR), but direct evidence is lacking. We used electron microscopy to examine how ASD CSR affect pyramidal neurons in the frontal cortex of mice, focusing on mitochondria, endosomes, lysosomes that together perform most basic cellular functions, from nutrient intake prevention stress.