Age-Related Differences in Sleep Architecture and Electroencephalogram in Adolescents in the National Consortium on Alcohol and Neurodevelopment in Adolescence Sample

• DOI: 10.5665/sleep.5978
• Publication Date: 2016-07-01T13:27:42Z
• Authors: Fiona C. Baker; Adrian R. Willoughby; de Zambotti Massi...; Peter L. Franzen; Devin Prouty; Harold Javitz; Brant Hasler; Duncan B. Clark; Ian M. Colrain
• Keywords: Sleep architecture; Sleep; Sample (material)

To investigate age-related differences in polysomnographic and sleep electroencephalographic (EEG) measures, considering sex, pubertal stage, ethnicity, scalp topography a large group of adolescents the National Consortium on Alcohol NeuroDevelopment Adolescence (NCANDA). Following an adaptation/clinical screening night, 141 healthy (12–21 y, 64 girls) had recordings, from which staging EEG measures were derived. The setting was SRI International Human Sleep Laboratory University Pittsburgh Pediatric Laboratory. Older age associated with lower percentage N3 sleep, accompanied by higher percentages N2, N1, rapid eye movement (REM) sleep. boys compared younger more frequent awakenings wakefulness after onset, effects that absent girls. Delta (0.3–4 Hz) power nonrapid NREM older than at all electrode sites, steeper slopes decline over occipital scalp. frequency bands also adolescents, equal across electrodes. Percent delta first period similar age. African Americans (delta to sigma) Caucasians. Finally, replacing status models showed relationships. Substantial architecture evident adolescence this group, sex modifying some Establishment follow-up cohort allows investigation EEG-brain structural relationships effect behaviors, such as alcohol substance use, maturation. Data presented here sample male female show substantial electroencephalogram critical development. Age generally larger for boys, who disturbed age, There is power, scalp, particularly region. However, there no difference percent period, suggesting stability homeostatic mechanisms adolescence. Longitudinal tracking will allow changes conjunction brain changes, well how adolescent behaviors affect maturation electroencephalogram.