Drug-Excipient Compatibility Testing of Cilostazol Using FTIR and DSC Analysis

• DOI: 10.56899/152.6a.08
• Publication Date: 2024-09-12T08:01:45Z
• Authors: Syrine Faith Diño; Alia Denise Edu; Ralph Gean Francisco; Emmanuel Gutierrez; Perlita Crucis; April Mergelle Lapuz; Rogie Royce Caran...; Kevin Jace Miranda
• Keywords: Cilostazol; Excipient; Polyvinylpyrrolidone; Microcrystalline

Cilostazol possesses pharmacological restrictions, such as its absorption being limited by dissolution rate, and formulation studies must be employed accordingly to generate an optimized formulation. A drug-excipient compatibility analysis is conducted determine any interactions that may affect the in order guarantee stability, bioavailability, manufacturability of solid dosage forms. To identify incompatibilities, cilostazol alone combination with individual excipients microcrystalline cellulose, crospovidone, magnesium stearate, isopropyl alcohol, sodium lauryl sulfate, polyvinylpyrrolidone K30, corn starch were subjected Fourier-transform infrared spectroscopy (FTIR) equipped attenuated total reflectance method heat-flow differential scanning calorimetry (DSC) a temperature ranging from 30–400 °C at 10 °C/min ramp rate. The FTIR combined revealed no evidence chemical or physical instability. Minor changes appearance absorbance bands comparison can seen primarily due characterization excipients, but characteristic peaks still present. As for DSC analysis, % difference cilostazol's principal peak showed significant change. This implies incompatibilities exist between excipients.