Theta Rhythmopathy as a Cause of Cognitive Disability in TLE

• DOI: 10.5698/1535-7511.17.2.107
• Publication Date: 2017-05-03T15:17:52Z
• Authors: Tristan Shuman; Benjamin Amendolara; Peyman Golshani
• Keywords: 0301 basic medicine; 03 medical and health sciences; 0302 clinical medicine

Memory difficulties are commonly associated with temporal lobe epilepsy (TLE) and cause significant disability. This article reviews the role of altered hippocampal theta oscillations and theta-gamma coupling as potential causes of memory disturbance in temporal lobe epilepsy, dissecting the potential mechanisms underlying these changes in large-scale neuronal synchronization. We discuss development of treatments for cognitive dysfunction directed at restoring theta rhythmicity and future directions for research.