Multiple Cytokines-Producing Pleomorphic Carcinoma of Lung with Metastasis to the Small Intestine

• DOI: 10.5761/atcs.cr.13-00202
• Publication Date: 2013-11-07T22:53:29Z
• Authors: Satoshi Hara; Keita Hosoi; Yasuhiko Suga; Tetsuo Takata; Hiroyuki Degami; Yoshinori Kinoshita; Kyongyob Min
• Keywords: Diagnostic Imaging; Male; Lung Neoplasms; Tumor Necrosis Factor-alpha; Neoplasms, Second Primary; Adenocarcinoma; Middle Aged; 3. Good health; 03 medical and health sciences; C-Reactive Protein; Fatal Outcome; 0302 clinical medicine; Granulocyte Colony-Stimulating Factor; Intestinal Neoplasms; Intestine, Small; Biomarkers, Tumor; Humans; Pneumonectomy

A 58-year-old man underwent upper lobectomy for primary pleomorphic carcinoma of the lung. Nine months later, the pleomorphic carcinoma was recurred with marked peripheral leukocytosis and an elevated C-reactive protein. Chest and abdominal computed tomography (CT) revealed enlarged mediastinal lymph nodes and a bulky tumor in the small intestine. An enterectomy was performed and the intestinal tumor was removed. Immunostaining revealed tumor cells positive for G-CSF and TNF-α as well as an increased level of serum G-CSF and TNF-α. We describe a rare case of G-CSF and TNF-α producing pleomorphic carcinoma of the lung with metastasis to the small intestine.