Gender Differences in Predictors and Long-Term Mortality of New-Onset Postoperative Atrial Fibrillation Following Isolated Aortic Valve Replacement Surgery

• DOI: 10.5761/atcs.oa.19-00314
• Publication Date: 2020-04-27T22:08:04Z
• Authors: Mariana Fragão-Ma...; Jennifer Mancio; João Oliveira; Inês Falcão-Pires; Adelino Leite-Mor...
• Keywords: Aged, 80 and over; Heart Valve Prosthesis Implantation; Male; Time Factors; Aortic Valve Stenosis; Middle Aged; Risk Assessment; Severity of Illness Index; 03 medical and health sciences; Sex Factors; Treatment Outcome; 0302 clinical medicine; Risk Factors; Aortic Valve; Atrial Fibrillation; Humans; Original Article; Female; Hospital Mortality; 10. No inequality; Aged; Retrospective Studies

Postoperative atrial fibrillation (POAF) after coronary artery bypass grafting (CABG) has been associated with increased risk of death in women but not in men. We aimed to explore predictors and long-term mortality in POAF following isolated aortic valve replacement (AVR) surgery in men and women.This study included 379 severe aortic stenosis patients with no prior atrial fibrillation (AF) who underwent isolated AVR surgery. We used multiple logistic regression to investigate independent gender-specific predictors of new-onset POAF, and we performed Kaplan-Meier (KM) to determine the impact of POAF in long-term mortality according to gender.Advanced age and coronary artery disease prevalence were higher among POAF patients in both genders. On multiple analysis, increased postoperative peak lactate was independently associated with POAF in men, while lower mean aortic valve gradient was associated with POAF in women. Area under the curve (AUC) for the model was 0.77 [0.68-0.86] and 0.69 [0.60-0.78] for men and women, respectively. At 4-year follow-up, POAF was linked to increased risk of death in men but not in women.In severe aortic stenosis, factors associated with POAF and its impact on mortality differed between genders, with an increased risk of death observed only in men.