Clinical Characteristics of Patients with Hepatocellular Carcinoma in a Middle Eastern Population

• DOI: 10.5812/hepatmon.7612
• Publication Date: 2013-06-02T06:39:54Z
• Authors: Khalid A. Alswat; Faisal M. Sanai; Mansour Altuwaijri; Ali Albenmousa; Majid Almadi; Waleed K. Al-Hamoudi; Ayman A. Abdo
• Keywords: Portal vein thrombosis; Liver disease; Hepatic Encephalopathy; Univariate analysis; Hepatitis B; Hepatitis C

Hepatocellular carcinoma (HCC) is one of the leading causes death in Saudi male patients. Local clinical and demographic data this disease are scarce.We sought to describe characteristics outcomes patients from two tertiary care centers Arabia.Data were collected for all diagnosed have hepatocellular between June 2003 July 2008 who had been registered a special research database (the Observatory Liver Disease Registry (SOLID)). Data extracted SOLID clinical, biochemical, radiologic parameters outcome.Data was available 363 patients, mean age diagnosis 66 years, 74% males, Hepatitis C underlying cause liver 48%, while B 29%. Most at an advanced stage, 53 % CLIP score 4 6 (advanced stage), 55% large multi-nodular tumors 16% vascular invasion or extra-hepatic spread time diagnosis. decompensated cirrhosis; with child-pogh 44% 26% presence portal hypertension 55%. Forty eight percent died during study period. Predictors poor survival univariate analysis were; vein thrombosis (P = 0.03), < 0.0001), ascites 0.022), hepatic encephalopathy child-pough bilirubin > 22 0.0001) INR 1.2 0.02). On multivariate analysis, only hypertension, severe significant adjusted hazard ratio 1.6 (95% CI; 1.04-2.47), 1.76 1.12-2.8), 3.18 1.42-7.14) respectively.The cohort indicates that most HCC present late tumor stages, when prognosis usually dismal. Regular cancer surveillance cirrhotic might change outcomes. Further studies results treatment community needed.