Distribution of Hepatitis C Virus Genotypes in Iranian Chronic Infected Patients

• DOI: 10.5812/hepatmon.7991
• Publication Date: 2013-01-31T07:40:05Z
• Authors: Fatemeh Jahanbakh...; Hossein Keyvani; Seyed Hamidreza M...; Seyed Moayed Alavian; Shahin Fakhim; Farah Bokharaei-S...
• Keywords: Kowsar; Liver disease; Southern Iran; Hepatitis C

Hepatitis C virus (HCV) has different genotypes throughout the world. Since determination of which antiviral treatment to be applied is related HCV genotypes, identification an individual's prior therapy critical.The purpose this study was investigate distribution in a large population Iranian infected patients.Eleven thousand, five hundred and sixty one patients with chronic infection referred hospitals Tehran University Medical Sciences Center-Clinical Department Baqiyatallah Research Center for Gastroeneterology Liver Disease from March 2003 December 2011 were enrolled. Following extraction viral RNA serum, HCV-RNA detected using reverse transcriptase-nested polymerase chain reaction (RT-nested PCR) then analyzed by restriction fragment length polymorphism (RFLP) assay.The mean age 37.6 ± 14.2 years (range: 1-87). The highest frequency noted subtype 1a (44.9%) followed 3a (39.6%), 1b (11.3%). Mixed also found 2.5% total cases. Subtype most frequent genotype over 40 (46.1% versus 42.4%) under old (41.5% 38.9%).This suggested that dominant among 3a.