Metabolomic Biomarkers in the Diagnosis of Non-Alcoholic Fatty Liver Disease

• DOI: 10.5812/hepatmon.92244
• Publication Date: 2019-09-15T08:17:05Z
• Authors: Saeed Chashmniam; Mohsen Ghafourpour; Azam Rezaei Farimani; Ali Gholami; Bibi Fatemeh Noba...
• Keywords: Glycocholic acid; Metabolome; Deoxycholic acid; Pentadecanoic acid; Taurocholic acid

Background: Nonalcoholic fatty liver disease (NAFLD) is the most abundant chronic disorder, because racial and ethnic differences may influence prevalence severity of NAFLD. Objectives: This metabolomic study was conducted to identify metabolic biomarkers determine mechanism progress NAFLD in Iranian patients. Methods: Serum samples were collected from 75 participants (37 healthy controls 38 patients with NAFLD) after an overnight fast. The metabolome all determined by nuclear magnetic resonance (NMR) compared multivariate statistical analysis. Results: Totally, 19 identified NMR. Compared controls, had increased serum concentrations glycochenodeoxycholic acid, taurocholic glycocholic deoxycholic valine, isoleucine, succinic isocitric 2-ketoglutaric trimethylamine, proline, hydroxyproline tyrosine, while butyric propionic isovaleric glutamine, glycine, serine decreased. Conclusions: A robust set for diagnosis established. metabolomics revealed changes some amino acids their derivatives, bile acids, short chain tricarboxylic acid cycle intermediates subjects controls. These markers could be used as indicators regarding efficacy therapeutic interventions.