Adverse Events of GLP-1 Receptor Agonists for Weight Loss: Twitter and a National Pharmacovigilance Database

• DOI: 10.58502/dtt.23.0003
• Publication Date: 2023-03-24T08:28:18Z
• Authors: Hyun-Myung Back; Seo-A Choi; Myeong Gyu Kim

Glucagon-like peptide-1 (GLP-1) receptor agonists became the most prescribed drugs for weight loss.This study aimed to investigate adverse events of GLP-1 using Twitter and KIDS-KAERS database (KIDS-KD).116 Korean tweets on 1,701 liraglutide-adverse event combinations from KIDS-KD were used analysis.The common nausea (37.76%), vomiting (12.59%), dyspepsia (9.79%), dizziness (4.90%), somnolence (4.90%) Twitter.Adverse observed in post-marketing surveillance such as somnolence, myalgia, chest pain/ discomfort, parosmia found Twitter.In KIDS-KD, injection site rash (13.46%), pruritus (10.76%), (10.64%), (6.41%), reaction (5.29%) commonly reported.Signals (reporting odds ratio [ROR] = 616.1),injection (ROR 477.7),vomiting 2.4), 222.0),pruritus 2.5), bruising 45.8),injection pain 36.3).Subgroup analysis revealed that (n 16, ROR 46.6)and acne 3, 39.2) met signal criteria men women, respectively.Twitter identified not clinical trials, subgroup suggested possibility being a safety signal.Social media useful pharmacovigilance.