Differentiating Cerebral Amyloid Angiopathy From Alzheimer’s Disease Using Dual Amyloid and Tau Positron Emission Tomography

• DOI: 10.5853/jos.2024.02376
• Publication Date: 2025-01-31T07:39:28Z
• Authors: Hsin-Hsi Tsai; Marco Pasi; Chia-Ju Liu; Ya-Chin Tsai; Ruoh-Fang Yen; Ya-Fang Chen; Jiann-Shing Jeng; Li-Kai Tsai; Andreas Charidimou; Jean-Claude Baron
• Keywords: Amyloid (mycology); β amyloid

Although amyloid positron emission tomography (PET) might provide a molecular diagnosis for cerebral angiopathy (CAA), it does not have sufficient specificity this condition relative to incipient Alzheimer's disease (AD). To identify regional uptake pattern specific CAA, we attempted reduce overlap by selecting "pure CAA" (i.e., fulfilling the criteria probable CAA but without tau PET AD signature) and AD" positive presence of signature, lobar hemorrhagic lesions). We hypothesized that occipital tracer whole cortex (WC) would be higher in patients with pure may serve as diagnostic marker. Patients who fulfilled these were identified. In addition region interest (ROI), assessed frontal posterior cingulate (PCC) ROIs are sensitive AD. Amyloid was expressed absolute standardized value ratio (SUVR) ROI/WC ratio. The utility using Youden index cutoff. Eighteen 42 CAAs comparable age eligible. occipital/WC significantly than (1.02 [0.97-1.06] vs. 0.95 [0.87-1.01], P=0.001), an area under curve 0.762 (95% confidence interval [CI] 0.635-0.889) 72.2% CI 46.5-90.3) at cutoff (0.98). lobe, PCC WC SUVRs lower frontal/WC PCC/WC ratios did differ between groups. Using stringent patient selection minimize between-condition overlap, study demonstrated