Vaccination with apoptosis colorectal cancer cell pulsed autologous dendritic cells in advanced colorectal cancer patients: Report from a clinical observation

• DOI: 10.5897/ajb10.2054
• Publication Date: 2011-03-21
• Authors: CQ Bao; Cong Jin; BH Xu; YL Gu; JP Li; X Lu
• Keywords: Tolerability; Carcinoembryonic antigen; Cancer vaccine

To investigate vaccination with apoptosis colorectal cancer (CRC) cell pulsed autologous dendritic cells (DCs) in advanced CRC, 14 patients were enrolled and treated DCs vaccine to assess toxicity, tolerability, immune clinical responses the vaccine. No severe toxicity was observed well tolerated. The levels of interleukin-2 (IL-2), interleukin-12 (IL-12) interferon-γ (IFN-γ) significantly increased after (P < 0.05). Mean carcinoembryonic antigen (CEA) lever decreased from 99.5 71.4 ng/ml. Five showed a positive skin response apoptotic loaded DC vaccines delayed type hypersensitivity (DTH). In five DTH patients, we found patient lymphoglandulae coeliacae metastasis; temporary seroperitoneum regression demonstrated by CT scan full immunizations during 12 weeks. However, rescan 6 weeks new lesions on abdomen as re-growth primary lesion. During two years observation, all survived first year, while survival rate 80 20% second year owing advancement CRC. conclusion, strategy for pulsed-DCs may raise CRC activating Th1 responses. Furthermore, indications both immunologic effect heavily pretreated cancer. Key words : Dendritic cells, immunotherapy,