Neurotherapeutic effect of allopurinol against brain injury in hyperlipidemic rats

• DOI: 10.5897/ajpp2014.4247
• Publication Date: 2016-01-12T08:20:32Z
• Authors: A A Salama Abeer; M M Ibrahim Bassant
• Keywords: Hyperlipidemia; Allopurinol; Creatine kinase; Malondialdehyde

Hyperlipidemia is characterized by abnormally elevated levels of lipids and positively associated with cerebrovascular diseases. The aim the present study was evaluation possible effects allopurinol against brain injury in hyperlipidemic rats. induced maintaining rats on high fat diet for 6 weeks. prepared adding 1% cholesterol powder, 0.2% cholic acid, 10% to rat powdered standard laboratory diet., At end 4th week animals were treated fluvastatin (2.5 mg/kg, p.o) three dose (50, 100 200 concomitant hypercaloric 2 Assessment activity grid floor cage done at zero time period. Blood drawn biochemical assays as serum cholesterol, triglyceride, liver transaminases creatine kinase levels. Brains isolated determination malondialdehyde (MDA) reduced glutathione (GSH) contents well finally histopathological study. High -induced hyperlipidemia a reduction an elevation transaminase. treatment improves transaminase, ameliorates MDA GSH attenuates karyolysis. These results suggest that has antihyperlipidemic properties its complications modulation lipid profile oxidative stress. Key words: Allopurinol, activity, injury, hyperlipidemia,