Maternal and foetal toxicity induced by exposure to mixture of dimethoate and cypermethrin in albino rats

• DOI: 10.5897/jtehs2017.0381
• Publication Date: 2017-06-27T11:32:34Z
• Authors: B. Ramon-Yusuf S.; O. Aliu Y.; A. Salawu O.; Chahoud I.; F. Ambali S.
• Keywords: Litter; Lethal dose; Median lethal dose

The use of pesticide mixture to combat increased resistance by pest, single chemical insecticide has brought about an increase in the from different class, with its attendant toxicity. objective this study was evaluate maternal and foetal toxicity associated dimethoate cypermethrin, two insecticides that are normally mixed reduce pest resistance. 100 confirmed-mated (gravid) females were assigned at random among four groups (control – tap water only):   group 1- very low dose-10 mg/kg/day Cypermethrin (5.3% LD50) + 1.0 Dimethoate (0.7% LD50); 2- intermediate dose- 19 (10% 1.4 mg/kg/day  (0.9% 3- high dose-  38 (20% 12.8 (8.5% LD50). regimens administered orally gestation days (GD) 6-20 pregnant rats. dams examined for mortality, moribundity, pertinent behavioural changes signs overt Animals weighed on day 0, once every 3-day intervals during dosing period GD 21. rats sacrificed decapitation 21, uteri removed fetuses litter weight, size, resorption, sex ratio, absolute relative organ weight. results showed combined exposure caused toxic dams. However, body weight not adversely affected except heart significant alteration. Although, compromised, result prenatal decreased size offsprings’ male/female ratio. concludes co-exposure cypermethrin adverse consequences some parameters albino Key words: Pesticide mixture,