The Relationship of Disorders in the Hemostasis System with Changes in Homeostasis in Conditions of Progressive Inflammation

• DOI: 10.59315/jiscpp.2023-2-2.42-48
• Publication Date: 2024-07-15T16:44:32Z
• Authors: Sh-A Al-Kubaysi; T. Kumaksheva; N. Myshkina; E. Kozina; E. Ivanova; K. Madonov; D. Sardaeva; T. Vlasova
• Keywords: Homeostasis

The urgency of the problem acute peritonitis in surgical practice is due to annual increase morbidity, a high number complications, therapeutic complexity and mortality. Materials methods. material study was 45 patients with peritonitis, who were divided into 3 groups depending on course pathology after surgery. first group (n=15) – without second wound third tertiary sepsis. In addition standard research methods, laboratory tests are included determine severity intoxication, oxidative activity, state blood coagulation system, functional liver. period 1st, 5th, 10th postoperative day. Results. results showed that early surgery hypercoagulemia, inhibition fibrinolysis correlate lipid peroxidation, endogenous violation status With effective therapy, during period, hemostasis system homeostasis indicators corrected against background restoration aggravation phenomena inflammation development there progression changes studied further sepsis, modified form hypocoagulemia activation sharp peroxidation greater liver, including from its hemostasis-regulating component. Conclusions. obtained indicate presence reliable correlation disorders conditions progressive inflammation.