The effects of Rheum tanguticum polysaccharide on the polarization of Th1 and Th2 cells in TNBS-induced colitis in murine

• DOI: 10.59566/ijbs.2005.1023
• Publication Date: 2023-12-21T17:03:27Z
• Authors: Qi-Bing Mei; Liu Li; Zhi-Peng Wang; Yu-Mei Zhou; Hua Zhang; Yin Long; Jia-Yun Liu
• Keywords: Therapeutic effect

Inflammatory bowel diseases (IBDs) are chronic inflammatory intestinal disorders that characterized by thickened colon walls, ulcerations, including two forms of ulcerative colitis (UC) and Crohn's disease (CD). UC CD share some similar clinico-pathological characteristics but their causes opposite. The imbalance in cytokinesis produced Th1 Th2 cells, the subunit CD4+ T plays a key role development IBDs. Although traditional treatment for IBDs is effective to patients, it has numerous adverse-effects such as immuno-depression. In our previous study we found therapeutic effects Rheum tanguticum polysaccharide (RTP) on CD. Our present investigation focuses comparison RTP (200 mg/kg-1, once day five days) induced trinitrobenzene sulfonic acid (TNBS)/ethanol BALB/c mice TNBS SD rats. mechanism was investigated using immuno-histochemistry, Elisa assay, flow cytometry western-blot analysis. results showed had significant both index weight were significantly attenuated after while MPO activity RTP-treated animals markedly lower than administration (P<0.05, P<0.01). also inhibitory expansion CD4+T cells simultaneously improving polarization (P<0.01). conclusion, appears poses all pre-requisites be applied intervention, thus, offering hope