The Control of Stress Induced Type I Diabetes Mellitus in Humans through the Hepatic Synthesis of Insulin by the Stimulation of Nitric Oxide Production

• DOI: 10.59566/ijbs.2012.8171
• Publication Date: 2023-09-19T10:13:34Z
• Authors: Asru K. Sinha; Gorachand Bhattac...; ; Rajeshwary Ghosh; Rabindra Bhattach...
• Keywords: Sodium nitroprusside

The role of stress induced development Type-1 diabetes mellitus (T1DM) as opposed to autoimmunity remains obscure. It has been reported that a protein, identified be dermcidin isoform 2 (dermcidin) inhibited insulin synthesis in both the pancreatic β cells and hepatic cells. As effect could neutralized by increased production systemic nitric oxide (NO), investigations were carried out determine feasibility controlling T1DM through neutralization increase NO. To plasma level subjects (n=45), if any, when determined, it was found protein 65% participating volunteers. Efforts made normalize glucose (median=175 mg/dL) these NO applying cotton pad containing 0.28mmol sodium nitroprusside on abdominal skin. decreased blood 275 mg/dL (median) 115 volunteers within 24 h with concomitant from 7.5 μunits/dL 101 at same time. accompanied decrease 124.5 nM 18 0.43 ± 0.19 4.1 1.56 nM. results suggested controlled which consequence led insulin.