Genetic/Familial High-Risk Assessment: Breast and Ovarian

• DOI: 10.6004/jnccn.2010.0043
• Publication Date: 2017-04-14T15:57:31Z
• Authors: Mary B. Daly; Jennifer E. Axilbund; Saundra Buys; Beth Crawford; Carolyn D. Farrell; Susan Friedman; Judy E. Garber; Salil Goorha; Stephen B. Gruber; Heather Hampel; Virginia Kaklamani; Wendy Kohlmann; Allison Kurian; Jennifer Litton; P. Kelly Marcom; Robert Nussbaum; Kenneth Offit; Tuya Pal; Boris Pasche; Robert Pilarski; Gwen Reiser; Kristen Mahoney S...; Jeffrey R. Smith; Elizabeth Swisher; Jeffrey N. Weitzel
• Keywords: BRCA2 Protein; Ovarian Neoplasms; BRCA1 Protein; Breast Self-Examination; Breast Neoplasms; Genetic Counseling; Risk Assessment; United States; Li-Fraumeni Syndrome; 03 medical and health sciences; 0302 clinical medicine; Humans; Female; Genetic Predisposition to Disease; Genetic Testing; Hamartoma Syndrome, Multiple

All cancers develop as a result of mutations in certain genes, such those involved the regulation cell growth and/or DNA repair, 1,2 but not all these are inherited from parent.For example, sporadic can occur somatic/ tumor cells only, and de novo for first time germ (i.e., egg or sperm) fertilized itself during early embryogen-