Pediatric Central Nervous System Cancers, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology.

Pediatric cancer
DOI: 10.6004/jnccn.2022.0062 Publication Date: 2022-12-01
ABSTRACT
Central nervous system (CNS) cancers account for approximately one quarter of all pediatric tumors and are the leading cause cancer-related death in children. More than 4,000 brain CNS diagnosed each year children teens, incidence rate has remained stagnant recent years. The most common malignant gliomas, embryonal consisting predominately medulloblastomas, germ cell tumors. inaugural version NCCN Guidelines Pediatric Nervous System Cancers focuses on diagnosis management patients with diffuse high-grade gliomas. information contained is designed to help clinicians navigate complex prognosis these highly aggressive generally poor, 5-year survival rates <20% despite use combined modality therapies surgery, radiation therapy systemic therapy. Recent advances molecular profiling expanded targeted whose harbor certain alterations. However, enrollment a clinical trial preferred treatment eligible patients.
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