A single-nucleotide polymorphism in transferrin is associated with soluble transferrin receptor in Chinese adolescents.

• DOI: 10.6133/apjcn.112016.04
• Publication Date: 2017-09-18
• Authors: Wei Piao; Li Wang; Ting Zhang; Zhen Wang; Shaofang Shangguan; Jing Sun; Junsheng Huo
• Keywords: Soluble transferrin receptor; Transferrin receptor

Associations between genetic variants in the hepcidin regulation pathway and iron status have been reported previous studies. Most of these studies were conducted populations European descent relatively few Chinese populations. In this study, we evaluated associations single-nucleotide polymorphisms (SNPs) pathway, serum ferritin (SF) soluble transferrin receptor (sTfR) adolescents.In total, 692 students from rural boarding schools selected six cities China. The participants divided into case control groups according to criteria for SF sTfR. Furthermore, 33 SNPs TMPRSS6, TF, TFR2, BMP2, BMP4, HJV, CYBRD1, HFE, IL6, PCSK7, HAMP, KIAA1468, SRPRB selected. or sTfR detected.For SF, rs4820268 TMPRSS6 was associated with an <25 ng/mL status. Carriers G/G genotype exhibited significantly lower levels than A allele carriers did (p=0.047). For sTfR, rs1880669 rs4901474 rs7536827 HJV >=4.4 mg/L However, general linear model analysis, after adjustment age, sex, location, only a stable association higher (p=0.032).We found rs4820268, that low level, as previously reported, new 1880669 TF