The long non-coding RNA CCAT1 promotes erlotinib resistance in cholangiocarcinoma by inducing epithelial-mesenchymal transition via the miR-181a-5p/ROCK2 axis

• DOI: 10.62347/eqdk1844
• Publication Date: 2024-06-28T04:08:31Z
• Authors: Wei Zhou
• Keywords: Circular RNA; ROCK2

Cholangiocarcinoma (CCA) is a common malignancy of the digestive system, and its treatment greatly challenged by rising chemoresistance. Long non-coding RNAs (lncRNAs) have been shown to play critical roles in development drug resistance tumors. However, role lncRNA CCAT1 erlotinib CCA remains unclear. In this investigation, we identified as pivotal factor contributing CCA. Furthermore, uncovered that modulated epithelial-mesenchymal transition (EMT) through Rho-associated coiled-coil-forming protein kinase 2 (ROCK2), thereby conferring upon cells. Mechanistically, demonstrated miR-181a-5p interacted with modulate expression ROCK2. Collectively, these findings shed light on significant The functional suppression holds promise enhancing sensitivity reversing EMT miR-181a-5p/ROCK2 signaling pathway. These provide valuable insights into mechanisms underlying potential strategies for treatment.