Stressful Life Events and Neuroticism among Chinese Women with Recurrent Major Depressive Disorder

• DOI: 10.62641/aep.v53i2.1730
• Publication Date: 2025-03-05T04:19:50Z
• Authors: Fengfeng Chu; Chu Wang; Shufei Tao; Jingfang Gao; Xiangzhen Zhu; Danhong Tao; Bijun Chen; Ming Tao

Depression is associated with a high incidence of stressful life events (SLEs) and neuroticism. However, the impact SLEs neuroticism on recurrence major depressive disorder (MDD) remains unclear. Therefore, we aimed to identify potential causal relationship between SLEs, neuroticism, depression recurrence. This study included 5561 female patients recurrent MDD (ages 30-60) 4257 healthy volunteers 40-60) from China, Oxford, Virginia Commonwealth University Experimental Research Genetic Epidemiology (CONVERGE) study. We compared gender age-matched group volunteers. Odds ratios (ORs) were calculated using logistic regression analysis assess onset. Furthermore, employed bootstrapping sampling procedures explore mediating role number episodes. contributed occurrence depression, rape (OR = 19.14, p 0.004), serious neglect 3.65, < 0.001), legal problems 2.51, divorce or breakup 2.14, 0.001) being significantly onset MDD. Following onset, certain such as death family member (Z 3.64, unemployment 5.63, job termination 6.43, financial crisis 5.53, led significant increase in mediation demonstrated that (p 0.05), physical abuse 0.05) indirectly affected episodes through Our demonstrates different categories have effects MDD, their regarding personal maltreatment, interpersonal relationship, finance are mediated by