GFAP as a marker of reactive astrocytes in the mice brain following hemorrhagic stroke and HSV-I

• DOI: 10.7124/bc.000965
• Publication Date: 2020-06-13T13:21:10Z
• Authors: A. V. Gumenyuk; S. L. Rybalko; S. I. Savosko; M. M. Guzyk; A. O. Tykhomyrov; A. A. Ryzha; Yu. B. Chaikovsky
• Keywords: Stroke; HSL and HSV

Aim.To investigate reactive changes of GFAP-positive astrocytes as a marker brain response following hemorrhagic stroke and HSV-I.Methods.The experiments were performed on 110 Balb/c mice weighing 18-20 g.The animals infected with HSV type I, 30 day was simulated in determined by immunohistochemistry. Gliosis confirmed density arborization astrocytes.Results.The results immunohistochemical studies increased the hippocampus I well sharp increase hypertrophy simulation animals.Conclusions.The experiment has provided new evidence about location level astrocytic gliosis herpes infection.GFAP can be studied reactivation against stroke.K e y w o r d s: GFAP, astrocytes,