Gender Differences in Histamine-Induced Depolarization and Inward Currents in Vagal Ganglion Neurons in Rats

• DOI: 10.7150/ijbs.7595
• Publication Date: 2014-01-16T11:14:02Z
• Authors: Jun-Nan Li; Zhao Qian; Wen-Xiao Xu; Bing Xu; Xiao-Long Lu; Zhen-Yu Yan; Li-Min Han; Yang Liu; Mei Yuan; John Schild; Guo-Fen Qiao; Bai-Yan Li
• Keywords: Male; Neurons; Ovariectomy; Vagus Nerve; Membrane Potentials; Rats; Rats, Sprague-Dawley; 03 medical and health sciences; Sex Factors; 0302 clinical medicine; Animals, Newborn; 5. Gender equality; Animals; Female; Ganglia; 10. No inequality; Myelin Sheath; Research Paper; Histamine

Evidence has shown gender differences regarding the critical roles of histamine in prevalence asthma, anaphylaxis, and angina pectoris.Histamine depolarizes unmyelinated C-type neurons without any effects on myelinated A-type vagal ganglion (VGNs) male rats.However, little is known if VGNs from females react to a similar manner.Membrane depolarization inward currents were tested isolated adult rats using whole-cell patch technique.Results males consistent with literature.Surprisingly, histamine-induced observed both Aand Ah-type female rats.In neurons, responses 1.0 µM stronger intact than significantly reduced ovariectomized (OVX) females.In events smaller (pA/pF) compared this activity was dramatically increased by OVX.Female A-types responded histamine, which further following ovariectomy.Histamine at 300 nM depolarized Ah-types females, but not OVX contrast, sensitivity A-and C-types upregulated OVX.These data demonstrate VGN chemosensitivity for first time.Myelinated showed highest across populations, changed novel findings improve understanding pain.Changes may explain alterations certain pathophysiological conditions when women reach postmenopausal age.