Glidobactins A, B and C, new antitumor antibiotics. I. Production, isolation, chemical properties and biological activity.

• DOI: 10.7164/antibiotics.41.1331
• Publication Date: 2012-03-01T03:40:20Z
• Authors: MASAHISA OKA; YUJI NISHIYAMA; SHINICHI OHTA; HIDEO KAMEI; MASATAKA KONISHI; TAKEO MIYAKI; TOSHIKAZU OKI; HIROSHI KAWAGUCHI
• Keywords: Male; 0301 basic medicine; Antibiotics, Antineoplastic; Magnetic Resonance Spectroscopy; Chemical Phenomena; Spectrophotometry, Infrared; Leukemia P388; Lysine; Fungi; Melanoma, Experimental; Microbial Sensitivity Tests; Peptides, Cyclic; 3. Good health; Chemistry; Mice; 03 medical and health sciences; Animals; Female; Myxococcales; Drug Screening Assays, Antitumor; Leukemia L1210

New antitumor antibiotic glidobactins A, B and C were isolated from the cultured broth of a gliding bacterium, Polyangium brachysporum sp. nov. No. K481-B101. They are novel molecules carrying the common cyclic tripeptide nucleus substituted with different alpha, beta, gamma, delta-unsaturated fatty acids. Glidobactins exhibit broad inhibitory activity against fungi and yeasts, and prolong the life span of mice inoculated with P388 leukemia cells.