Temporal trends of liver cancer burden, comparative analysis of risk factors and trend forecasts to 2024 in China, USA, the Republic of Korea, and Mongolia: an analysis based on multiple data sources from Global Burden of Disease 2019, the Global Cancer Observatory, and Cancer Incidence in Five Continents

• DOI: 10.7189/jogh.15.04040
• Publication Date: 2025-01-31T09:04:27Z
• Authors: Xing Yao; Xinchun Ling; Ziyi Zhu; Xiaolu Cao; Shaoliang Tang
• Keywords: Liver Cancer

Liver cancer represents a significant burden of disease globally, with variations in liver status among countries. In this study, we aimed to evaluate the epidemiological four representative countries - China, USA, Republic Korea, and Mongolia cover highest number incidence cases, prevalence rates developed addition, intended predict trends these over next six years. We collected data on from Global Burden Disease 2019, Cancer Observatory, Incidence Five Continents databases conduct source triangulation. calculated time using Joinpoint regression predicted an autoregressive integrated moving average model. Aetiological studies were conducted for different based changes causes. Between 1990-2019, age-standardised (ASR) values declined globally. The downward trend was most pronounced where annual percentage change rate (ASIR) reached -3.13 (95% confidence interval (CI) = -2.90, -3.35), much higher than world -1.16 CI -0.96, -1.36). ASIR USA continued improving 5.23 × 105 2019. With age, ASR various generally shows upward trend. Hepatitis B virus (HBV) remains main causative agent China Korea. Mongolia, both HBV hepatitis C account large proportion cancer. cases alcohol consumption has increased annually. past 30 years but worsened some due ageing unhealthy lifestyles.