Helicobacter pylori prevalence in dyspeptic patients in the Eastern Cape province - race and disease status

• DOI: 10.7196/samj.4041
• Publication Date: 2016-04-08T15:53:55Z
• Authors: N F Tanih; B I Okeleye; L M Ndip; A M Clarke; N Naidoo; N Mkwetshana; E Green; R N Ndip
• Keywords: Cape

Objectives. We examined Helicobacter pylori infection in patients with gastric-related morbidities at Livingstone Hospital, Port Elizabeth, to determine the prevalence and risk factors for according race, endoscopic diagnosis, age sex. Methods. Gastric biopsies were collected from 254 consecutive H. isolated on Columbia agar base supplemented 7% sheep's blood Skirrow's supplement containing trimethoprim (2.5 mg), vancomycin (5 mg) cefsulodin mg). Amphotericin was added medium. Recovered isolates identified following standard microbiology biochemical techniques. Presumptive further confirmed by polymerase chain reaction (PCR) targeting glmM gene. Fisher's exact test used assess univariate association between possible factors. Odds ratios (ORs) corresponding 95% confidence intervals (CIs) calculated measure strength of association, using EPI INFO 3.41 software. P-values <0.05 required significance. Results. The overall 66.1% (168/254). Of 168 positive subjects, highest non-ulcer dyspepsia (NUD) (32.7%; 55/168), lowest (0%; 0/168) those atypical oesophageal reflux disease gastroduodenitis, respectively. among coloureds (68.4%; 89/130) whites (59.5%; 25/ 42). Prevalence increased age. Conclusion. is high dyspeptic Eastern Cape Province. Gender, antibiotic treatment alcohol consumption may be infection. These findings are clinical epidemiological