Multivariate analysis of prognostic factors in patients with stage IB cervical cancer who underwent radical hysterectomy

• DOI: 10.7197/cmj.v32i4.1008000309
• Publication Date: 2010-12-23
• Authors: Taner Turan; Alev Özer; Abdullah Boztosun; Fatma Önalan; Nurettin Boran; Yetki̇n Karasu; Gökhan Tulunay; Mehmet Faruk Köse
• Keywords: Lymphovascular invasion; Lymphadenectomy; Univariate analysis; Adjuvant Therapy

Abstract Aim. The aim of this study was to assess the effects prognostic factors on survival cervical cancer patients. Methods. Data obtained from 193 patients who had been diagnosed as stage IB and underwent a type III radical hysterectomy systematic bilateral pelvic plus para-aortic lymphadenectomy between 1993 2007 were reviewed. Results. Twenty-three excluded they have lost follow-up immediately after surgery. Mean age 53 years median follow up 62 months. During follow-up, recurrence developed in 27 patients, while 26 died. In univariate analysis, presence metastasis any lymph node, involvement or nodes adjuvant radiotherapy significant terms disease free (DFS) overall (OS) rate. Age lymphovascular space invasion only for OS rate, whereas depth stromal DFS Tumor size, stage, cell type, grade, parametrial involvement, positive surgical margins no value. multivariate node found independent both OS. Stromal an factor DFS. However, significance therapy. Conclusion. present study, status important among those determining with high risk early hysterectomy. Furthermore, it that also effect rate much had. Key words: Cervical cancer, factors. Ozet Amac. Bu calismada serviks kanserinde prognostik etkisi oldugu dusunulen faktorlerin yasam oranlari uzerindeki degerlendirildi. Yontem. 1993-2007 tarihleri arasinda evre kanseri tanisi alan, tip radikal histerektomi ve sistematik pelvik+para-aortik lenfadenektomi geciren hastanin verileri gozden gecirildi. Bulgular. 23 hasta cerrahiden hemen sonra kontrollere gelmediginden calisma disi birakildi. Degerlendirilen 170 yas ortalamasi yildi, ortanca takip suresi aydi. sure icinde hastada nuks gelistigi belirlendi. Univaryant analizde herhangi bir lenf nodunda metastaz varligi, pelvik veya para-aortik nodu tutulumu adjuvan radyoterapi hastaliksiz orani sag kalim icin anlamliydi. Yas lenfovaskuler alan invazyonu sadece icin, invazyon derinligiyse anlam tasimaktaydi. boyutu, evre, hucre tipi, grade , tutulum cerrahi sinir pozitifliginin degerinin olmadigi goruldu. Multivaryant ise yasin, hem hemde OS bagimsiz faktorler saptandi. faktordu. Buna karsin tutulumu, radyoterapinin anlamli Sonuc. erken evrede sonrasi yuksek-riskli grubu belirleyen faktorlerden durumunun onemli Bunun yani sira yasin durumu kadar uzerine etkili Anahtar sozcukler: Serviks kanseri, Prognostik