Single Oral Dose Toxicity Test of ACM(Added Chongmyung-tang) in Sprague-Dawley Rat

• DOI: 10.7231/jon.2012.23.2.021
• Publication Date: 2012-08-20T03:57:37Z
• Authors: Woo-Chang Choi; In-Chul Jung; Jong-Soon Lim; Seung-Hyung Kim; Sang-Ryong Lee
• Keywords: 0301 basic medicine; 03 medical and health sciences; 3. Good health

AbstractObjectives :This research investigates the single oral dose toxicity of ACM in SD rats.Methods :ACMs were administered to female and male SD rats, as an oral d ose of 5000 ㎎/㎏. Animals were monitored for the mortality and changes in the body weight, clinical signs and gross observation during the 14 days after dosing, upon necropsy. Results :We could not find any mortality. Compared with the control grou p, significant weight change was not observed in the experimental group. First day after administration, compoun d-colored stool was observed in all rats. After the second day of administration, the more common symptoms were not observed . There were no gross abnormalities in all cases. [ED NOTE: highlight: given the context, this is very vague]Conclusions :The results obtained in this study suggest that the approximate lethal dose of ACM in both female and male rats were considered as over 5000 ㎎/㎏. Key Words:ACM, Added Chongmyung-Tang, single oral dose toxicity, SD rats Received : May 25, 2012; Revised : June 07, 2012; Accepted : Ju ne 21, 2012Correspondence : Sang-Ryong Lee, Address : Daejon Univ. College of Oriental Medicine, Yongun-dong, Dong-gu, Daejeon, KoreaTel : 043-229-3726, Fax : [phone], E-mail : [e-mail]*This study was supported by a grant of the Traditional Korean Medicine R&D Project, Ministry of Health & Welfare, Republic of Korea. (Task-specific number: B090020)